Achievements

Drug Discovery and Development Division

1. Balkrishna, A.; Rustagi, Y.; Tomar, M.; Pokhrel, S.; Bhattacharya, K.; Varshney, A. Divya-Arjuna-Kwath (Terminalia arjuna) and Divya-HridyAmrit-Vati ameliorate isoproterenol-induced hypertrophy in murine cardiomyocytes through modulation of oxidative stress.Phytomedicine Plus 2021,100074.

https://www.sciencedirect.com/science/article/pii/S2667031321000567

2.Balkrishna, A.; Raj, P.; Singh, P.; Varshney, A. Influence of Patient-Reported Treatment Satisfaction on Psychological Health and Quality of Life Among Patients Receiving Divya-Swasari-Coronil-Kit Against COVID-19: Findings from a Cross-Sectional “SATISFACTION COVID” Survey. Dovepress 2021, 15,899

https://www.dovepress.com/influence-of-patient-reported-treatment-satisfaction-on-psychological--peer-reviewed-fulltext-article-PPA

3. Balkrishna, A.; Gohel, V.; Singh, R.; Bhattacharya, K.; Varshney, A. Livogrit ameliorates acetaldehyde-induced steatosis in HepG2 cells through modulation of lipogenesis and β-oxidation pathways. Phytomedicine Plus 2021, 100067

https://www.sciencedirect.com/science/article/pii/S266703132100049X

4.Balkrishna, A.; Solleti, S.K.; Singh, H.; Sharma, N.; Varshney, A. Withanolides from Withania somnifera Ameliorate Neutrophil Infiltration in Endotoxin-Induced Peritonitis by Regulating Oxidative Stress and Inflammatory Cytokines. Planta Medica 2021.

https://pubmed.ncbi.nlm.nih.gov/33862643/

5. Balkrishna, A.; Khandrika, L.; Varshney, A. Giloy Ghanvati (Tinospora cordifolia (Willd.) Hook. f. and Thomson) Reversed SARS-CoV-2 Viral-Spike-Protein Induced Disease Phenotype in the Xenotransplant Model of Humanized Zebrafish. Frontiers in Pharmacology 2021, 12,534

https://www.frontiersin.org/articles/10.3389/fphar.2021.635510/full

6. Balkrishna, A.; Verma, S.; Sharma, P.; Tomer, S.; Srivastava, J.; Varshney, A, Comprehensive and Rapid Quality Evaluation Method for the Ayurvedic Medicine Divya-Swasari-Vati Using Two Analytical Techniques: UPLC/QToF MS and HPLC–DAD. Pharmaceuticals 2021, 14, 4,297

https://www.mdpi.com/1424-8247/14/4/297

7. Balkrishna, A.; Devpura, G; Tomar, B.S.; Nathiya, D.; Sharma, A.; Bhandari, D.; Haldar, S.; Varshney. A, Randomized placebo-controlled pilot clinical trial on the efficacy of ayurvedic treatment regime on COVID-19 positive patients. Phytomedicine 2021, 84, 153494.

https://www.sciencedirect.com/science/article/pii/S0944711321000362

8. Balkrishna, A.; Gupta, A.K.; Singh, K.; Haldar, S.; Varshney, A. Effects of fatty acids in super critical fluid extracted fixed oil from Withania somnifera seeds on Gram-negative Salmonella enterica biofilms. Phytomedicine Plus 2021, 100047.

https://www.sciencedirect.com/science/article/pii/S2667031321000294

9. Balkrishna, A.; Pokhrel, S.; Varshney, A. Phyto-compounds from a rather poisonous plant, Strychnos nux-vomica, show high potency against SARS-CoV-2 RNA-dependent RNA polymerase. Current Molecular Medicine 2021.

https://europepmc.org/article/med/33602083

10. Balkrishna, A.; Haldar, S.; Singh, H.; Roy, P.; Varshney, A. Coronil, a Tri-Herbal Formulation, Attenuates Spike-Protein-Mediated SARS-CoV-2 Viral Entry into Human Alveolar Epithelial Cells and Pro-Inflammatory Cytokines Production by Inhibiting Spike Protein-ACE-2 Interaction. Journal of Inflammation Research 2021, 14,869.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981146/

11. Balkrishna, A.; Pokhrel, S.; Singh, H.; Joshi, M.; Mulay, V.P.; Haldar, S.; Varshney, A. Withanone from Withania somnifera attenuates SARS-CoV-2 RBD and host ACE2 interactions to rescue spike protein induced pathologies in humanized zebrafish model. Drug Design, Development and Therapy 2021, 15, 1111.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961299/

12. Balkrishna, A.; Nain, P.; Joshi, M.; Khandrika, L.; Varshney, A. Supercritical Fluid Extract of Putranjiva roxburghii Wall. Seeds Mitigates Fertility Impairment in a Zebrafish Model. Molecules 2021, 26, 4, 1020.

https://www.mdpi.com/1420-3049/26/4/1020

1. Balkrishna, A.; Singh. K.; Singh, H.; Haldar, S.; Varshney, A. GermiX: A skin friendly hand sanitizer with prolonged effectivity against pathogenic bacteria. AMB Express 2020, 10, 210.

amb-express.springeropen.com/articles/10.1186/s13568-020-01151-y

2. (A) Balkrishna, A.; Solleti, S.K.; Verma, S.; Varshney, A. Application of Humanized Zebrafish Model in the Suppression of SARS-CoV-2 Spike Protein Induced Pathology by Tri-Herbal Medicine Coronil via Cytokine Modulation. Molecules 2020, 25, 5091..

mdpi.com/1420-3049/25/21/5091

2. (B) Here is the video to explain Coronil tablet – how we have combined Traditional knowledge (Ayurveda) and exhaustive scientific methods

3. Balkrishna, A.; Sakat, S.S.; Ranjan, R.; Joshi, K.; Shukla, S.; Joshi, K.; Verma, S.; Gupta, A.; Bhattacharya, K.; Varshney, A. Polyherbal Medicine Divya Sarva-Kalp-Kwath Ameliorates Persistent Carbon Tetrachloride Induced Biochemical and Pathological Liver Impairments in Wistar Rats and in HepG2 Cells. Frontiers in Pharmacology 2020, 11.288

ncbi.nlm.nih.gov/pmc/articles/PMC7109321/

4. Balkrishna, A.; Gohel, V.; Singh, R.; Joshi, M.; Varshney, Y.; Jyotish, S.; Bhattacharya, K.; Varshney, A. Tri-Herbal Medicine Divya Sarva-Kalp-Kwath (Livogrit) Regulates Fatty Acid-Induced Steatosis in Human HepG2 Cells through Inhibition of Intracellular Triglycerides and Extracellular Glycerol Levels Molecules 2020, 25, 4849

mdpi.com/1420-3049/25/20/4849

5. Balkrishna, A.; Nain, P.; Chauhan, A.; Sharma, N.; Gupta, A.; Ranjan, R.; Varshney, A. Super Critical Fluid Extracted Fatty Acids from Withania somnifera Seeds Repair Psoriasis-Like Skin Lesions and Attenuate Pro-Inflammatory Cytokines (TNF-α and IL-6) Release. Biomolecules 2020, 10, 185

mdpi.com/2218-273X/10/2/185

6. Balkrishna, A.; Pokhrel, S.; Singh, J.; Varshney, A. Withanone from Withania somnifera may inhibit novel Coronavirus (COVID-19) entry by disrupting interactions between viral S-protein receptor binding domain and host ACE2 receptor. Research Gate 2020.

researchsquare.com/article/rs-17806/latest.pdf

7. Balkrishna, A.; Rustagi, Y.; Bhattacharya, K.; Varshney, A. Application of Zebrafish Model in the Suppression of Drug-Induced Cardiac Hypertrophy by Traditional Indian Medicine Yogendra Ras. Biomolecules 2020, 10, 600

mdpi.com/2218-273X/10/4/600

8. Balkrishna, A.; Pokhrel, S.; Varshney, A. Tinospora cordifolia (Giloy) may curb COVID-19 contagion: Tinocordiside disrupts the electrostatic interactions between ACE2 and RBD. Authorea Preprints, 2020

europepmc.org/article/med/33172372

9. Balkrishna, A.; Solleti, S.K.; Singh, H.; Tomer, M.; Sharma, N.; Varshney, A. Calcio-herbal formulation, Divya-Swasari-Ras, alleviates chronic inflammation and suppresses airway remodelling in mouse model of allergic asthma by modulating pro-inflammatory cytokine response. Biomedicine & Pharmacotherapy 2020, 126, 110063

sciencedirect.com/science/article/pii/S0753332220302547

10. Balkrishna, A.; Pokhrel, S.; Varshney, A. Comparative COX I Molecular Docking of Phyto-chemicals (Flavonoids, Alkaloids, Lignans and Terpenoids) for Anti-platelet Aggregation Dynamics. Current Computer-Aided Drug Design 2020, 16

scholar.google.com/scholar?oi=bibs&cluster=18370721165824573238&btnI=1&hl=en

11. Balkrishna, A.; Solleti, S.K.; Verma, S.; Varshney, A. Validation of a novel zebrafish model of dengue virus (DENV-3) pathology using the pentaherbal medicine Denguenil Vati. Biomolecules 2020, 10, 971

mdpi.com/2218-273X/10/7/971

12. Balkrishna, A.; Sakat, S.S.; Karumuri, S.; Singh, H.; Tomer, M.; Kumar, A.; Sharma, N.; Nain, P.; Haldar, S.; Varshney, A. Herbal Decoction Divya-Peedantak-Kwath Alleviates Allodynia and Hyperalgesia in Mice Model of Chemotherapy-Induced Peripheral Neuropathy via Modulation in Cytokine Response. Frontiers in Pharmacology 2020, 11, 1664

scholar.google.com/scholar?oi=bibs&cluster=1330618317711019192&btnI=1&hl=en

13. Balkrishna, A.; Solleti, S.K.; Singh, H.; Verma, S.; Sharma, N.; Nain, P.; Varshney, A. Herbal decoction Divya-Swasari-Kwath attenuates airway inflammation and remodeling through Nrf-2 mediated antioxidant lung defence in mouse model of allergic asthma. Phytomedicine 2020, 78, 153925

sciencedirect.com/science/article/abs/pii/S0944711320301276

14. Balkrishna, A.; Pokhrel, S.; Varshney, A. Tinocordiside from Tinospora cordifolia (Giloy) May Curb SARS-CoV-2 Contagion by Disrupting the Electrostatic Interactions between Host ACE2 and Viral S-Protein Receptor Binding Domain. Combinatorial Chemistry & High Throughput Screening 2020

authorea.com/doi/full/10.22541/au.158707095.53639175

15. Balkrishna, A.; Thakur, P.; Singh, S.; Chandra Dev, SN.; Varshney, A. Mechanistic Paradigms of Natural Plant Metabolites as Remedial Candidates for Systemic Lupus Erythromatosus. Cells 2020, 9, 1049.

mdpi.com/2073-4409/9/4/1049/htm

16. Balkrishna, A.; Thakur, P.; Singh, S.; Chandra Dev, SN.; Jain,V.; Varshney, A.; Sharma, RK. Glucose antimetabolite 2-Deoxy-D-Glucose and its derivative as promising candidates for tackling COVID-19: Insights derived from in silico docking and molecular simulations. Authorea 2020

scholar.google.com/scholar?oi=bibs&cluster=16884986181427593854&btnI=1&hl=en

17. Balkrishna, A.; Das, S.K.; Joshi, A.; Sharma, V.; Bisht, L.; Das, N.; Sharma, N.; Shukla, S.; Mehra, D.; Joshi, K.; Dhara, S. Cellular internalization of Godanti Bhasma (anhydrous CaSO4) induces massive cytoplasmic reversible vacuolation and survival response of mammalian cells. bioRxiv 2020.

biorxiv.org/content/10.1101/2020.02.01.930594v2.abstract

18. Balkrishna, A.; Das, S.K.; Joshi, A.; Bisht, L.; Sakat, S.S.; Sharma, V.; Sharma,N.; Joshi, K.; Verma, S.; Sharma, V.K.; Joshi, CS. LC/MS-QToF Profiling, Anti-Diabetic and Anti-Adipogenic potential of Divya MadhuKalp: A Novel Herbo-mineral Formulation. bioRxiv 2020.

biorxiv.org/content/10.1101/2020.02.15.950865v2.abstract

19. Balkrishna, A.; Thakur, P.; Varshney, A. Phytochemical Profile, Pharmacological Attributes and Medicinal Properties of Convolvulus prostratus–A Cognitive Enhancer Herb for the Management of Neurodegenerative Etiologies. Frontiers in Pharmacology 2020, 11

ncbi.nlm.nih.gov/pmc/articles/PMC7063970/

20. Balkrishna, A.; Sharma,V.K.; Das, SK.; Mishra, N.; Bisht, L.; Joshi, A.; Sharma, N. Characterization and Anti-Cancerous Effect of Putranjiva roxburghii Seed Extract Mediated Silver Nanoparticles on Human Colon (HCT-116), Pancreatic (PANC-1) and Breast (MDA-MB 231) Cancer Cell Lines: A Comparative Study. International Journal of Nanomedicine 2020, 15, 573

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986406/

1. Balkrishna, A.; Sakat, S.S.; Joshi,K.; Paudel, S.; Joshi, D.; Joshi,K.; Ranjan, R.; Gupta, A.; Varshney, A. Herbo-mineral formulation ‘Ashwashila’attenuates rheumatoid arthritis symptoms in collagen-antibody-induced arthritis (CAIA) mice model. Scientific reports 2019, 9, 1-17

nature.com/articles/s41598-019-44485-9

2. Balkrishna, A.; Ranjan, R.; Sakat, S.S.; Sharma, V.K; Shukla,R; Joshi,K.; Devkar, R.; Sharma, N.; Saklani, A; Pathak, P.; Kumari, P.; Agarwal, V.R. Evaluation of polyherbal ayurvedic formulation ‘Peedantak Vati’for anti-inflammatory and analgesic properties. Journal of ethnopharmacology 2019, 235, 361-374

sciencedirect.com/science/article/abs/pii/S037887411733550X

3. Balkrishna, A.; Pokhrel,S.; Tomer,M.; Verma, S.; Kumar, A.; Nain, P.; Gupta, A.; Varshney, A. Anti-Acetylcholinesterase activities of mono-herbal extracts and exhibited synergistic effects of the phytoconstituents: a biochemical and computational study. Molecules 2019, 24, 4175

mdpi.com/1420-3049/24/22/4175

4. Balkrishna, A.; Sakat, S.S.; Joshi, K.; Joshi,K.; Sharma, VK.; Ranjan, R.; Bhattacharya, K.; Varshney, A. Cytokines Driven Anti-Inflammatory and Anti-Psoriasis Like Efficacies of Nutraceutical Seabuck Thorn (Hippophae rhamnoides) Oil. Frontiers in Pharmacology 2019, 10, 1186

frontiersin.org/articles/10.3389/fphar.2019.01186/full

5. Balkrishna, A.; Varshney, A.; Paudel, S.; Joshi,K.; Sakat, S.S.; Joshi, D. ; Joshi,K.; Ranjan, R Gupta, A.; Bhattacharya, K. Anti-Inflammatory and Anti-Arthritic Efficacies of an Indian Traditional Herbo-Mineral Medicine ‘Divya Amvatari Ras’ in Collagen Antibody-Induced Arthritis (CAIA) Mouse Model Through Modulation of IL-6/IL-1β/TNF-α/NFκB Signaling. Frontiers in Pharmacology 2019, 10, 659

frontiersin.org/articles/10.3389/fphar.2019.00659/full

6. Balkrishna, A.; Das,S.K.; Pokhrel, S.; Joshi,A.; Verma, S.; Sharma, V.K.; Sharma, V.; Sharma, N.; Joshi, C.S. Colchicine: Isolation, LC–MS QTof Screening, and Anticancer Activity Study of Gloriosa superba Seeds. Molecules 2019, 24, 2772

mdpi.com/1420-3049/24/15/2772/htm

Patanjali Herbal Research Department

  • Balkrishna et al. (2020). Agricultural mobile apps used in India: Current status and gap analysis. Agricultural Science Digest, (D-5140). (Accepted)
  • Balkrishna et al. (2020). Analysis of policy interventions in agriculture and ICT based mechanistic approach towards sustainability: An Indian perspective. Asian Journal of Agriculture and Rural Development. (Accepted)

  • Balkrishna et al. (2018). New Plant Records to the Flora of Haryana. Indian Journal of Forestry.
  • Balkrishna et al. (2018). Phytoresources of Morni Hills, Panchkula, Haryana. Indian Journal of Forestry.
  • Balkrishna et al. (2018). Phytoetymology and ethnobotany of indigenous or introduced gymnosperms in India. International Journal of Unani and Integrative Medicine, 2(4), 44-51.
  • Balkrishna et al. (2018). Life-form and Biological Spectrum of Morni Hills, Panchkula, Haryana. Indian Journal of Forestry, 41(3) 299-302. ISSN: 0971-9431. NAAS Rating 3.78 India.
  • Balkrishna et al. (2018). Etymology of Endemic Plants of Uttarakhand, India. International Journal of Forest Usufructs Management, 19: 66-69. ISSN: 0972-3927. NAAS Rating 3.23 India.
  • Balkrishna et al. (2018). Phyto-resources of Morni Hills, Panchkula, Haryana. Journal of Non-Timber Forest Products, 25(2) 91-98. ISSN: 0971-9415. NAAS Rating 3.59 India.
  • Balkrishna et al. (2018). New Plant Records to the Flora of Haryana. Indian Journal of Forestry, 41(2) 117-127. ISSN: 0971-9431. NAAS Rating 3.78 India.
  • Balkrishna et al. (2018). Medicinal Plants of Morni Hills, Shivalik Range, Panchkula, Haryana. Journal of Non-Timber Forest Products, 25(1) 1-14. ISSN: 0971-9415. NAAS Rating 3.59 India.
  • Balkrishna et al. (2018). Medicinal Plants of Morni Hills, Shivalik Range, Panchkula, Haryana. Journal of Non-Timber Forest Products 25 (1) 1-14.
  • Saxena et al. (2017). Diversity, Ethnomedicinal Knowledge and Conservation Status of Plant Species used by the People in a Part of District Tehri Garhwal, North West Himalaya. Bulletin of Environment, Pharmacology and Life Sciences.

Yoga Research Division

  • Telles et al. (2020). Body temperature in practitioners of a yoga breathing technique considered to be heat generating (Accepted)
  • Sharma et al. (2020). Yoga as an add on therapy in the management of migraine. 2020. Indian J Community Medicine. (Accepted).
  • Telles et al. (2020). Body Temperature and Energy Expenditure During and After Yoga Breathing Practices Traditionally Described as Cooling. Medical Science Monitor Basic Research, 26, e920107.

  • Telles et al. (2019). The Impact of Yoga on Teachers' Self-Rated Emotions. BMC Research Notes, 12(1), 680.
  • Gupta et al. (2019). Performance in a Corsi Block-tapping Task following High-frequency Yoga Breathing or Breath Awareness. International Journal of Yoga, 12(3), 247–251.
  • Telles et al. (2019). Immediate Effect of a Yoga Breathing Practice on Attention and Anxiety in Pre-Teen Children. Children (Basel, Switzerland), 6(7), 84.
  • Telles et al. (2019). Mental Wellbeing, Quality of Life, and Perception of Chronic Illness in Yoga-Experienced Compared with Yoga-Naïve Patients. Medical Science Monitor Basic Research, 25, 153–163.
  • Telles et al. (2019). Changes in Shape and Size Discrimination and State Anxiety after Alternate-Nostril Yoga Breathing and Breath Awareness in One Session Each. Medical Science Monitor Basic Research, 25, 121–127.
  • Telles et al. (2019). Quality of Life in Yoga Experienced and Yoga Naïve Asian Indian Adults with Obesity. Journal of obesity, 2019, 9895074.
  • Telles et al. (2019). Yoga as a Holistic Treatment for Chronic Illnesses: Minimizing adverse events and safety concerns. Frontiers in Psychology, 10:661.
  • Telles et al. (2019). Effect of yoga on vigilance, self-ratedhave sleep and state anxiety in Border Security Force personnel in India. Work, 63(2):243-251.
  • Gulati et al. (2019). Self Esteem and Performance in Attentional Tasks in School Children after 4½ Months of Yoga. International Journal of Yoga, 12(2):158-161.
  • Telles et al. (2018). Anthropometric variables as predictors of aspects of quality of life in persons with central obesity. BMC Research Notes, 11(1):680
  • Pal et al. (2018). Neurophysiological Changes Determined by the EEG with Yoga Breathing Practices: A Mini Review. EC Neurology, 10(9).
  • Telles et al. (2018). Twelve Weeks of Yoga or Nutritional Advice for Centrally Obese Adult Females. Frontiers in Endocrinology, 9:466.
  • Gupta et al. (2018). A Brief Overview of Yoga for Children with Physical and Mental Needs. EC Pediatrics, 7(8): 807-809.
  • Telles et al. (2018). Changes in vigilance, self rated sleep and state anxiety in military personnel in India following yoga. BMC Research Notes, 11: 518.
  • Telles et al. (2018). A Brief Overview of Yoga for Respiratory Disorders. EC Pulmonology and Respiratory Medicine, 7.8 (2018): 554-556.
  • Telles et al. (2018). Increased Mental Well-being and Reduced State Anxiety in Teachers After Participation in a Residential Yoga Program. Medical Science Monitor Basic Research, 24: 105–112.
  • Telles et al. (2018). The association between the Lipid Profile and Fasting Blood Glucose with Weight Related Outcomes in Healthy Obese Adults. BMC Research Notes, 11(1):383.
  • Telles et al. (2018). Changes in reaction time after yoga bellows type breathing in healthy female volunteers. International Journal of Yoga, 11(3):224-230
  • Gupta et al. (2018). Stress and coping strategies: The impact on health. Yoga Mimansa, 50(1):20-26.
  • Telles et al. (2017). Alternate-Nostril Yoga Breathing Reduced Blood Pressure While Increasing Performance in a Vigilance Test. Medical Science Monitor Basic Research, 23:392-398.
  • Balkrishna et al. (2017). The anatomy of the skin: concepts from ayurveda and computational modelling. Indian Journal of Clinical Anatomy and Physiology, 5(1).
  • Telles et al. (2017). Characteristics of Yoga Practitioners, Motivators and Yoga Techniques of Choice: A Cross-sectional Study. Frontiers in Public Health, 5, 184.
  • Telles et al. (2017). Hemisphere specific EEG related to alternate nostril yoga breathing. BMC Research Notes, 10 (1), 306
  • Telles et al. (2017). A critical evaluation of Dead Sea Therapy in the management of psoriasis. Journal of Alternative, Complementary and Integrative medicine, 3, 33.
  • Sharma et al. (2017). A comparision of the quality of life in obese persons based on experience of yoga practice. Indian Journal of Traditional Knowledge, 16 (suppl), 17-20.
  • Bharadwaj et al. (2017). The inter-dependence between beliefs and feelings about a yagna: a correlational study. Indian Journal of Traditional Knowledge, 16 (suppl), 25-29.
  • Telles et al. (2017). Yoga and Physiotherapy: Therapies Which Complement Each Other. Journal of Yoga and Phisiotherapy, 1(3).
  • Telles, S. (2017). Yoga and Healthy Eating: The Underlying Mechanisms. Journal of Yoga & Physical Therapy, 7 (1), 128.
  • Kumar et al. (2017). Phase change heat transfer during cryosurgery of lung cancer using hyperbolic heat conduction model. Computers in Biology and Medicine, 84, 20-29.
  • Bhardwaj et al. (2017). Yoga practice in a school setting positively impacts self-esteem: a 13-month follow-up study. Indian Journal of Physiology and Pharmacology, 61(1), 76-79.
  • Verma et al. (2017). Evaluation of the Protective Effects of Constituents of an Ayurveda Herbal Eye Drop Preparation in Albino Rabbits. International Journal of Medical Research Professionals, 3(1): 155-158.

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