In vivo Biology- Laboratory Animal Facility

In vivo Biology- Laboratory Animal Facility

The Patanjali Research Institute has well equipped laboratory animal facility for small animal experimentation with quarantine, holding, experimental and necropsy rooms for small rodents and rabbits. The facility has been registered (Registration No 1964/PO/Rc/S/17/CPCSEA) for experiments on animals under the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), Ministry of Environment, Forests and Climate Change, Government of India, New Delhi.

Animal experimentation are conducted under the guidance of Institutional Animal Ethics Committee (IAEC) with license to work on different experimental animals such as rats, mice, rabbits and guinea pigs. The facility has been constructed with clean and dirty corridor concept and is equipped with individually ventilated cages (IVCs) for handling immunocompromised animals, used to screen test compounds for anti-cancer activity, along with a well-equipped pathology lab, microbiology lab, biochemistry lab and Instrumentation laboratories. The animals are well maintained under controlled environmental conditions temperature (22±3°C), relative humidity (30-70 %), 12:12 h light and dark cycle. Dedicated scientists and trained animal house staff along with full time veterinarian are available to provide veterinary care to the animals. The facility is under electronic surveillance (CCTV system) and controlled access to authorized persons to minimize the risk of infection to the animals. Our highly qualified, experienced scientific team is currently focused in the therapeutic areas of metabolism, inflammation, autoimmunity, oncology, hepatic-gastroentrology and central nervous system. So far, we have successfully tested more than 50 ayurvedic test articles for these therapeutic areas using various standardized animal models like Carrageenan induced paw edema model, hot plate test, tail flick test, formalin test, acetic acid induced writhing test, Streptozotocin and high fat diet induced diabetes type 2, TPA or Imiquimod induced psoriasis, Collagen type II antibody induced arthritis (CAIA), Carbon tetrachloride induced hepatotoxicity in rodent models. Our mission is to validate ayurvedic, herbo-mineral formulations using relevant animal models; to create a scientific body of evidence for their suggested usage; and to provide a global acceptance to the Ayurveda.

Research Planning

Internal Research

Research Planning on internal discoveries Synergies between chemistry and biology Animal Experimentation: Rats and Mice

External Research

External Outsourced Studies Pharmacology and Toxicology Animal models: Zebra Fish, Rat, Mice, Rabbit and Dog

 

Team In-vivo Biology

  • Dyslipidemia studies in rats
  • Memory Enhancing studies in mice
  • Pharmacokinetics studies for Bhasma
  • Diabetes Type II studies in rats
  • IMQ induced Psoriasis in rats
  • LPS induced Acute Lung Injury in rats
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